Journal article
Centrosome function is critical during terminal erythroid differentiation
- Abstract:
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Red blood cells are produced by terminal erythroid differentiation, which involves the dramatic morphological transformation of erythroblasts into enucleated reticulocytes. Microtubules are important for enucleation, but it is not known if the centrosome, a key microtubule-organizing center, is required as well. Mice lacking the conserved centrosome component, CDK5RAP2, are likely to have defective erythroid differentiation because they develop macrocytic anemia. Here, we show that fetal live...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 7.9MB, Terms of use)
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- Publisher copy:
- 10.15252/embj.2021108739
Authors
Bibliographic Details
- Publisher:
- EMBO Press
- Journal:
- EMBO Journal More from this journal
- Article number:
- e108739
- Publication date:
- 2022-06-09
- Acceptance date:
- 2022-05-25
- DOI:
- EISSN:
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1460-2075
- ISSN:
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0261-4189
- Pmid:
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35678476
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1264126
- Local pid:
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pubs:1264126
- Deposit date:
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2022-07-14
Terms of use
- Copyright holder:
- Tátrai and Gergely
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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