Journal article
Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy
- Abstract:
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How chemotherapy affects carcinoma genomes is largely unknown. Here we report whole-exome and deep sequencing of 30 paired oesophageal adenocarcinomas sampled before and after neo-adjuvant chemotherapy. Most, but not all, good responders pass through genetic bottlenecks, a feature associated with higher mutation burden pre-treatment. Some poor responders pass through bottlenecks, but re-grow by the time of surgical resection, suggesting a missed therapeutic opportunity. Cancers often show maj...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 663.8KB)
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- Publisher copy:
- 10.1038/ncomms11111
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature communications Journal website
- Volume:
- 7
- Pages:
- 11111
- Publication date:
- 2016-04-05
- Acceptance date:
- 2016-02-21
- DOI:
- EISSN:
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2041-1723
- Source identifiers:
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614034
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:614034
- UUID:
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uuid:23b1ee0d-e56f-4796-a7c0-fec413a3ccbf
- Local pid:
- pubs:614034
- Deposit date:
- 2016-04-12
Terms of use
- Copyright holder:
- Findlay et al
- Copyright date:
- 2016
- Notes:
-
This work is licensed under a Creative Commons Attribution 4.0
International License. The images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise
in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material.
To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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