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Journal article

Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy

Abstract:

How chemotherapy affects carcinoma genomes is largely unknown. Here we report whole-exome and deep sequencing of 30 paired oesophageal adenocarcinomas sampled before and after neo-adjuvant chemotherapy. Most, but not all, good responders pass through genetic bottlenecks, a feature associated with higher mutation burden pre-treatment. Some poor responders pass through bottlenecks, but re-grow by the time of surgical resection, suggesting a missed therapeutic opportunity. Cancers often show maj...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms11111

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Tomlinson, I
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature communications Journal website
Volume:
7
Pages:
11111
Publication date:
2016-04-05
Acceptance date:
2016-02-21
DOI:
EISSN:
2041-1723
Source identifiers:
614034
Language:
English
Keywords:
Pubs id:
pubs:614034
UUID:
uuid:23b1ee0d-e56f-4796-a7c0-fec413a3ccbf
Local pid:
pubs:614034
Deposit date:
2016-04-12

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