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Ras-induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation.

Abstract:

Using a reconstituted mouse prostate organ, the effects on endogenous p53 expression of the ras oncogene or of the ras + myc oncogenes were investigated. In this system the ras gene alone causes mild hyperplasia, but the combination of ras and myc leads to the formation of carcinomas. Surprisingly, while p53 mutations were found in cells derived from the reconstituted organs containing ras alone, no such mutations were found in the ras + myc-transformed cells. Their growth, unlike that of the...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Journal:
Cell
Volume:
70
Issue:
1
Pages:
153-161
Publication date:
1992-07-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
410256
Language:
English
Keywords:
Pubs id:
pubs:410256
UUID:
uuid:23ae8572-f8e3-4e89-8dc3-45fae8e26b98
Local pid:
pubs:410256
Deposit date:
2013-11-17

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