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The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria.

Abstract:

OBJECTIVE: Intravenous artesunate is commonly used in the emergency treatment of patients with severe falciparum malaria in Asia. The choice of doses used has been empirical. To inform dosage recommendations we assessed the pharmacokinetics of intravenous artesunate after the first dose. METHODS: As part of a clinical trial of artesunate in adults with severe falciparum malaria in western Thailand, we assayed plasma concentrations of artesunate and the principal biologically active metabolit...

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Publication status:
Published

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Publisher copy:
10.1007/s00228-006-0203-2

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
European journal of clinical pharmacology More from this journal
Volume:
62
Issue:
12
Pages:
1003-1009
Publication date:
2006-12-01
DOI:
EISSN:
1432-1041
ISSN:
0031-6970

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