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Journal article

Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European Prospective Investigation into Cancer-Eurgast cohort.

Abstract:

Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccharide and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an immune response. Single nucleotide polymorphisms (SNPs) in these genes have been associated with GC in different populations. We genotyped 30 SNPs of these genes, in 365 gastric adenocarcinomas and 1,284 matched controls ...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.28357

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Journal:
International journal of cancer. Journal international du cancer
Volume:
134
Issue:
1
Pages:
92-101
Publication date:
2014-01-01
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Source identifiers:
439636

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