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Functional significance of Na+/Ca2+ exchangers co-localization with ryanodine receptors.

Abstract:

Co-localization of Na+/Ca2+ exchangers (NCX) with ryanodine receptors (RyRs) is debated. We incorporate local NCX current in a biophysically detailed model of L-type Ca2+ channels (LCCs) and RyRs and study the effect of NCX on the regulation of Ca2+-induced Ca2+ release and the shape of the action potential. In canine ventricular cells, under pathological conditions, e.g., impaired LCCs, local NCXs become an enhancer of sarcoplasmic reticulum release. Under such conditions incorporation of lo...

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Publication status:
Published

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Publisher copy:
10.1196/annals.1387.047

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Annals of the New York Academy of Sciences More from this journal
Volume:
1099
Issue:
1
Pages:
215-220
Publication date:
2007-03-01
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
Language:
English
Keywords:
Pubs id:
pubs:237148
UUID:
uuid:23a600fc-7002-4625-99c4-6c656ae0adc0
Local pid:
pubs:237148
Source identifiers:
237148
Deposit date:
2013-11-16

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