An exploration of non-coding sequence variation across human erythroid differentiation

Thesis

The ability to precisely regulate genes has been pivotal in the evolution of complex life and humanity. A cell’s ability to dynamically control the 3D structure of the genome to physically bring together regulatory elements allows for the precise spatiotemporal expression of genes. Variation within the human genome is widespread and well documented, and accounts for the vast differences in phenotypes seen within a population. However, this variation can also lead to disease as the disrupti...

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Authors: Gosden, ME

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• DOI: 10.5287/ora-koyqmjdev
• Language: English
• Keywords: human genomics; gene regulation; erythropoiesis
• Subjects: Functional genomics