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Colorectal cancer and genetic alterations in the Wnt pathway.

Abstract:

In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the adenomatous polyposis coli (APC) gene. Germline mutations cause familial adenomatous polyposis and at least two-thirds of sporadic colorectal tumours also acquire APC mutations, quite possibly as the initiating events in tumorigenesis. These mutations almost always cause loss of the C-terminal functions of the APC protein - probably involved in microtubule binding, cell polarity and chromosome segregatio...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1210059

Authors


Segditsas, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Oncogene
Volume:
25
Issue:
57
Pages:
7531-7537
Publication date:
2006-12-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:239a3de9-fdcf-425a-b5a7-fe8e4fc468e7
Source identifiers:
72057
Local pid:
pubs:72057

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