Journal article
Colorectal cancer and genetic alterations in the Wnt pathway.
- Abstract:
-
In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the adenomatous polyposis coli (APC) gene. Germline mutations cause familial adenomatous polyposis and at least two-thirds of sporadic colorectal tumours also acquire APC mutations, quite possibly as the initiating events in tumorigenesis. These mutations almost always cause loss of the C-terminal functions of the APC protein - probably involved in microtubule binding, cell polarity and chromosome segregatio...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Oncogene
- Volume:
- 25
- Issue:
- 57
- Pages:
- 7531-7537
- Publication date:
- 2006-12-01
- DOI:
- EISSN:
-
1476-5594
- ISSN:
-
0950-9232
- Source identifiers:
-
72057
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:72057
- UUID:
-
uuid:239a3de9-fdcf-425a-b5a7-fe8e4fc468e7
- Local pid:
- pubs:72057
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2006
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