Coexpression of CD4 and CD8 on peripheral blood T cells and lamina propria T cells in inflammatory bowel disease by two colour immunofluorescence and flow cytometric analysis.

Journal article

Using two colour immunofluorescence with fluorescein isothiocyanate and phycoerythrin labelled monoclonal antibodies and multiparameter flow cytometry, we investigated the coexpression of CD4 and CD8 antigens on peripheral blood lymphocytes and lamina propria lymphocytes of patients with ulcerative colitis and Crohn's disease and normal control subjects. Both the absolute number and the proportion of peripheral blood CD4+, CD8+ cells in inflammatory bowel disease were small but significantly ...

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Authors: Senju, M; Wu, K; Mahida, Y; Jewell, D

• Publication status: Published
• Publisher: BMJ Publishing Group
• Journal: Gut
• Volume: 32
• Issue: 8
• Pages: 918-922
• Publication date: 1991-08-01
• DOI: 10.1136/gut.32.8.918
• EISSN: 1468-3288
• ISSN: 0017-5749
• Language: English
• Keywords: Fluorescent Antibody Technique; Colon; Flow Cytometry; Humans; Leukocyte Count; Colitis, Ulcerative; Antigens, CD4; Ileum; Crohn Disease; Lymphocyte Activation; T-Lymphocytes; Antigens, Differentiation, T-Lymphocyte