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Journal article

Characterisation of assembly and ubiquitylation by the RBCC motif of Trim5α

Abstract:

The post-entry restriction factor Trim5α blocks infection of retroviral pathogens shortly after the virus gains entry to the cell, preventing reverse transcription and integration into the host genome. Central to the mechanism of restriction is recognition of the lattice of capsid protein that forms the inner-shell of the retrovirus. To recognise this lattice, Trim5α has been shown to assemble into a large hexagonal array, complementary to the capsid lattice. Structures of the Trim5α coiled-c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep26837

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0003-0159-9257
More by this author
Role:
Author
ORCID:
0000-0003-0069-9408
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
26837
Publication date:
2016-05-27
Acceptance date:
2016-05-09
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
27230667
Source identifiers:
954508
Language:
English
Keywords:
Pubs id:
pubs:954508
UUID:
uuid:2386d2da-2665-4849-9cb4-68de6ef57ef3
Local pid:
pubs:954508
Deposit date:
2019-01-08

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