Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease.

Journal article

The identification of the role of genetic variants within NOD2 (CARD15) in Crohn's disease and ulcerative colitis susceptibility highlight the role of the innate immune system in inflammatory bowel disease (IBD) pathogenesis. NOD1 (CARD4) is located on chromosome 7p14.3, in a region of known linkage to IBD and encodes an intracellular bacterial pathogen-associated molecular pattern receptor that is closely related to NOD2. We have identified strong association between haplotypes in the termin...

Expand abstract

Authors: McGovern, D; Hysi, P; Ahmad, T; van Heel, D; Moffatt, M

• Publication status: Published
• Journal: Human molecular genetics
• Volume: 14
• Issue: 10
• Pages: 1245-1250
• Publication date: 2005-05-01
• DOI: 10.1093/hmg/ddi135
• EISSN: 1460-2083
• ISSN: 0964-6906
• Language: English
• Keywords: Humans; Middle Aged; Genetic Predisposition to Disease; Genetic Markers; Sequence Deletion; Nod1 Signaling Adaptor Protein; Polymorphism, Genetic; Male; Infant; Adolescent; Adaptor Proteins, Signal Transducing; Aged; Colitis, Ulcerative; Child, Preschool; Adult; Female; Child; Inflammatory Bowel Diseases; Crohn Disease; Aged, 80 and over; Linkage Disequilibrium