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Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study

Abstract:

Background Inflammatory processes have been shown to play a role in dementia. To understand this role, we selected two anti-inflammatory drugs (methotrexate and sulfasalazine) to study their association with dementia risk.

Methods A retrospective matched case-control study of patients over 50 with rheumatoid arthritis (486 dementia cases and 641 controls) who were identified from electronic health records in the UK, Spain, Denmark and the Netherlan...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13195-020-00606-5

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Division:
MSD
Department:
Psychiatry
Role:
Author
ORCID:
0000-0002-3001-1478
Publisher:
BioMed Central Publisher's website
Journal:
Alzheimer's Research and Therapy Journal website
Volume:
12
Article number:
38
Publication date:
2020-04-06
Acceptance date:
2020-03-19
DOI:
ISSN:
1758-9193
Language:
English
Keywords:
Pubs id:
1095388
Local pid:
pubs:1095388
Deposit date:
2020-03-20

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