- Abstract:
-
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show that the chemokine receptor XCR1 is expressed by tDCs, whereas medullary thymic epithelial cells (mTECs) express the ligand XCL1. XCL1-deficient mice are defective in the medullary accumulation of tDCs and the thymic generation of naturally o...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1084/jem.20102327
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 208
- Issue:
- 2
- Pages:
- 383-394
- Publication date:
- 2011-02-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:23743829-0f76-4843-ba1c-9072534637fd
- Source identifiers:
-
309054
- Local pid:
- pubs:309054
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.
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