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Effects of metformin on insulin resistance after injury in the rat.

Abstract:

Hyperglycaemia and insulin resistance occur after injury. The effects of the antidiabetic biguanide metformin in injured rats have been studied in order to elucidate the cause of these effects. Metformin (120 mg/kg S. C.) produced a significant hypoglycaemic effect after a 20% dorsal scald but did not affect the blood glucose concentration in non-injured rats. The hypoglycaemic effect did not result from increased insulin secretion. It was associated with a reduction in liver glycogen and an ...

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Publication status:
Published

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Publisher copy:
10.1007/bf01221965

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Diabetologia
Volume:
12
Issue:
1
Pages:
53-60
Publication date:
1976-03-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:236ed5fc-3bf3-40b8-b529-538ffee27317
Source identifiers:
27725
Local pid:
pubs:27725

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