Distribution of dendritic cell subtypes in primary oral squamous cell carcinoma is inconsistent with a functional response.

Journal article

Dendritic cell (DC) function will likely be important for immunological cancer therapies, but our knowledge of the roles of DCs in tumors is limited, in part because most studies were performed before DC subtypes were defined. We studied the distributions of immature epidermal, immature dermal, mature, and plasmacytoid DCs in 63 primary tumors and eight lymph node metastases from oral squamous cell carcinoma patients without evidence of distant metastasis. Immature CD207/Langerin+ and CD209/D...

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Authors: O'Donnell, R; Mick, R; Feldman, M; Hino, S; Wang, Y

• Publication status: Published
• Journal: Cancer letters
• Volume: 255
• Issue: 1
• Pages: 145-152
• Publication date: 2007-09-01
• DOI: 10.1016/j.canlet.2007.04.003
• EISSN: 1872-7980
• ISSN: 0304-3835
• Language: English
• Keywords: Neoplasms; Mouth Neoplasms; Dendritic Cells; Humans; Interleukin-3 Receptor alpha Subunit; Treatment Outcome; Carcinoma, Squamous Cell; Leukocytes; Middle Aged; Cell Adhesion Molecules; Female; Male; Neoplasm Invasiveness; Receptors, Cell Surface; Lymph Nodes; Plasmacytoma; Aged; Lectins, C-Type