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The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk.

Abstract:

The 'unopposed oestrogen hypothesis' for endometrial cancer maintains that risk is increased by exposure to endogenous or exogenous oestrogen that is not opposed simultaneously by a progestagen, and that this increased risk is due to the induced mitotic activity of the endometrial cells. Investigation of the mitotic rate during the menstrual cycle shows that increases in plasma oestrogen concentration above the relatively low levels of the early follicular phase do not produce any further inc...

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Publisher copy:
10.1038/bjc.1988.44

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
Journal:
British journal of cancer More from this journal
Volume:
57
Issue:
2
Pages:
205-212
Publication date:
1988-02-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Keywords:
Pubs id:
pubs:5337
UUID:
uuid:23651ab1-50b2-4b2e-b318-c8d5cccd9806
Local pid:
pubs:5337
Source identifiers:
5337
Deposit date:
2012-12-19

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