Journal article
Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.
- Abstract:
-
Chromatin structure is tightly intertwined with transcription regulation. Here we compared the chromosomal architectures of fetal and adult human erythroblasts and found that, globally, chromatin structures and compartments A/B are highly similar at both developmental stages. At a finer scale, we detected distinct folding patterns at the developmentally controlled β-globin locus. Specifically, new fetal stage-specific contacts were uncovered between a region separating the fetal (γ) and adult...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Cold Spring Harbour Laboratory Press Publisher's website
- Journal:
- Genes and Development Journal website
- Volume:
- 31
- Pages:
- 1704-1713
- Publication date:
- 2017-09-15
- Acceptance date:
- 2017-08-21
- DOI:
- EISSN:
-
1549-5477
- ISSN:
-
0890-9369
- Pmid:
-
28916711
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:730032
- UUID:
-
uuid:2363a4b5-17c0-41fb-8498-e54a603df1f4
- Local pid:
- pubs:730032
- Source identifiers:
-
730032
- Deposit date:
- 2019-02-28
Terms of use
- Copyright holder:
- Huang et al
- Copyright date:
- 2017
- Notes:
- © 2017 Huang et al.; Published by Cold Spring Harbor Laboratory Press. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date. After six months, it is available under a Creative Commons License.
- Licence:
- CC Attribution (CC BY)
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