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Journal article

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.

Abstract:

Chromatin structure is tightly intertwined with transcription regulation. Here we compared the chromosomal architectures of fetal and adult human erythroblasts and found that, globally, chromatin structures and compartments A/B are highly similar at both developmental stages. At a finer scale, we detected distinct folding patterns at the developmentally controlled β-globin locus. Specifically, new fetal stage-specific contacts were uncovered between a region separating the fetal (γ) and adult...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/gad.303461.117

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
ORCID:
0000-0002-4108-4357
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Name:
NIDDK NIH HHS
Grant:
R24 DK106766
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Name:
NHLBI NIH HHS
Grant:
U01 HL129998
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Name:
Medical Research Council
Grant:
MC_UU_12009/15
Publisher:
Cold Spring Harbour Laboratory Press
Journal:
Genes and Development More from this journal
Volume:
31
Pages:
1704-1713
Publication date:
2017-09-15
Acceptance date:
2017-08-21
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Pmid:
28916711
Language:
English
Keywords:
Pubs id:
pubs:730032
UUID:
uuid:2363a4b5-17c0-41fb-8498-e54a603df1f4
Local pid:
pubs:730032
Source identifiers:
730032
Deposit date:
2019-02-28

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