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Mechanisms of antibody immunotherapy on clonal islet reactive T cells.

Abstract:

Clinical intervention trials evaluating the efficacy of antibody immunotherapy in type 1 diabetes are in progress. We tested effects on prediabetic islet antigen-specific autoreactive T cells of antithymocyte globulin (ATG) and humanized monoclonal antibodies against CD3 (ChAglyCD3) or CD25 (daclizumab) with regard to downmodulation of the target protein, proliferation, cytokine production, complement-dependent cytotoxicity (CDC), antibody-dependent cell cytotoxicity (ADCC), and survival. ATG...

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Publication status:
Published

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Authors


van de Linde, P More by this author
Medema, JP More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Human immunology
Volume:
67
Issue:
4-5
Pages:
264-273
Publication date:
2006
DOI:
EISSN:
1879-1166
ISSN:
0198-8859
URN:
uuid:235ad8d5-394d-489c-84ec-824dc4ee69e3
Source identifiers:
4857
Local pid:
pubs:4857

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