A high affinity serotonin- and histamine-binding lipocalin from tick saliva.

Journal article

To overcome the inflammatory response in its host, the cattle-feeding, brown ear tick secretes histamine-binding proteins into the feeding site. These proteins are beta-barrels with two internal binding sites: a high-affinity (H) site for histamine and a site (L) for which the natural ligand is unknown. Here we report a related protein (SHBP), secreted by a rodent- and cattle-feeding tick, that traps both histamine and serotonin. The histamine-binding H site is well conserved in SHBP, whereas...

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Authors: Sangamnatdej, S; Paesen, G; Slovak, M; Nuttall, P

• Publication status: Published
• Journal: Insect molecular biology
• Volume: 11
• Issue: 1
• Pages: 79-86
• Publication date: 2002-02-01
• DOI: 10.1046/j.0962-1075.2001.00311.x
• EISSN: 1365-2583
• ISSN: 0962-1075
• Language: English
• Keywords: Histamine; Carrier Proteins; Spodoptera; Molecular Sequence Data; Animals; Serotonin; Cell Line; Dermacentor; Male; DNA, Complementary; Amino Acid Sequence; Female; Base Sequence