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Journal article

A high affinity serotonin- and histamine-binding lipocalin from tick saliva.

Abstract:

To overcome the inflammatory response in its host, the cattle-feeding, brown ear tick secretes histamine-binding proteins into the feeding site. These proteins are beta-barrels with two internal binding sites: a high-affinity (H) site for histamine and a site (L) for which the natural ligand is unknown. Here we report a related protein (SHBP), secreted by a rodent- and cattle-feeding tick, that traps both histamine and serotonin. The histamine-binding H site is well conserved in SHBP, whereas...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Journal:
Insect molecular biology More from this journal
Volume:
11
Issue:
1
Pages:
79-86
Publication date:
2002-02-01
DOI:
EISSN:
1365-2583
ISSN:
0962-1075
Language:
English
Keywords:
Pubs id:
pubs:276490
UUID:
uuid:23552aa1-79d3-4824-a89d-45bdf2f8fa58
Local pid:
pubs:276490
Source identifiers:
276490
Deposit date:
2013-11-16

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