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Journal article

Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycans.

Abstract:

Fertilization in mammals requires sperm to bind to the zona pellucida (ZP) that surrounds the egg. Galactose (Gal) or N-acetylglucosamine (GlcNAc) residues on the glycans of ZP protein 3 (ZP3) have been implicated as mouse sperm receptors. However, Mgat1(-/-) eggs with modified N-glycans lacking terminal Gal and GlcNAc residues are fertilized. To determine if Gal and GlcNAc on O-glycans of the ZP are required for fertilization, a conditional allele of the T-synthase gene (T-syn(F)) was genera...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.004291

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, Obstetrics and Gynaecology
Role:
Author
Journal:
Journal of cell science
Volume:
120
Issue:
Pt 8
Pages:
1341-1349
Publication date:
2007-04-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:234bc947-7147-45b9-bac1-15bcf33b8230
Source identifiers:
314628
Local pid:
pubs:314628

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