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Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.

Abstract:

BACKGROUND: Exploiting synteny between mouse and human disease loci has been proposed as a cost-effective method for the identification of human susceptibility genes. Here we explore its utility in an analysis of a human personality trait, neuroticism, which can be modeled in mice by tests of emotionality. We investigated a mouse emotionality locus on chromosome 1 that contains no annotated genes but abuts four regulators of G protein signaling, one of which (rgs2) has been previously identi...

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Publication status:
Published

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Journal:
Biological psychiatry More from this journal
Volume:
63
Issue:
9
Pages:
874-883
Publication date:
2008-05-01
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
Language:
English
Keywords:
Pubs id:
pubs:34081
UUID:
uuid:234982bf-1dec-4651-85df-e914a8cd7174
Local pid:
pubs:34081
Source identifiers:
34081
Deposit date:
2012-12-19

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