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The TGFBR1*6A/9A polymorphism is not associated with differential risk of breast cancer.

Abstract:

A polymorphic 9-bp deletion in exon 1 of TGFBR1 (TGFBR1*6A) has been identified as a low-penetrance cancer susceptibility allele. The strongest association in the initial studies was with breast cancer; however, these studies included patients with different types of cancer, including colon, cervical and breast carcinomas, with only a small proportion being breast cancer patients. In subsequent case-control studies focussing on breast cancer alone, the results have been equivocal. In order to...

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Publication status:
Published

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Publisher copy:
10.1007/s10549-009-0395-0

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Journal:
Breast cancer research and treatment More from this journal
Volume:
119
Issue:
2
Pages:
437-442
Publication date:
2010-01-01
DOI:
EISSN:
1573-7217
ISSN:
0167-6806

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