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Local adenoviral expression of Fas ligand upregulates pro-inflammatory immune responses in the CNS.

Abstract:

The central nervous system (CNS) is a site of relative immunological privilege; despite this it can be a target of the immune system under certain conditions. For example, adenoviral vectors elicit an immune response strong enough to result in antigen elimination, in immunologically primed animals. Fas ligand (FasL) contributes to the immune privilege of certain tissues by inducing apoptosis in activated T cells. We therefore investigated whether local overexpression of FasL could downregulat...

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Publisher copy:
10.1038/sj.gt.3302322

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Gene therapy
Volume:
11
Issue:
19
Pages:
1462-1474
Publication date:
2004-10-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:23449924-62a3-4f5e-9bd8-401cbeb81eda
Source identifiers:
113491
Local pid:
pubs:113491

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