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Local adenoviral expression of Fas ligand upregulates pro-inflammatory immune responses in the CNS.

Abstract:

The central nervous system (CNS) is a site of relative immunological privilege; despite this it can be a target of the immune system under certain conditions. For example, adenoviral vectors elicit an immune response strong enough to result in antigen elimination, in immunologically primed animals. Fas ligand (FasL) contributes to the immune privilege of certain tissues by inducing apoptosis in activated T cells. We therefore investigated whether local overexpression of FasL could downregulat...

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Publisher copy:
10.1038/sj.gt.3302322

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Gene therapy
Volume:
11
Issue:
19
Pages:
1462-1474
Publication date:
2004-10-01
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
Source identifiers:
113491
Language:
English
Keywords:
Pubs id:
pubs:113491
UUID:
uuid:23449924-62a3-4f5e-9bd8-401cbeb81eda
Local pid:
pubs:113491
Deposit date:
2013-11-17

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