Genomic epidemiology of meningococcal vaccine antigens in the United Kingdom

Thesis

Vaccination against Neisseria meningitidis remains the optimal means to prevent invasive meningococcal disease (IMD), an important cause of septicaemia and meningitis disproportionately affecting infants and young children. Subcapsular protein-based vaccines were developed to offer broad protection against genetic lineages of meningococci responsible for endemic capsular group B IMD. As meningococci solely colonise the human oropharynx, the inherent variation in surface proteins p...

Expand abstract

Authors: Rodrigues, C

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Invasive meningococcal disease; Genomic epidemiology; Molecular epidemiology; Neisseria meningitis; Protein-based vaccines; Genomics; Meningococci; Meningococcal vaccines; Bacteria; Vaccines; Whole genome sequencing; Genomic surveillance
• Subjects: Meningococcal disease; Bacterial genomics; Vaccine