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Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia.

Abstract:

BACKGROUND: Evidence suggests that children with familial hypercholesterolemia (FH) have endothelial dysfunction. Inflammatory and haemostatic abnormalities are associated with advanced atherosclerosis and increased cardiovascular events. However, it is unknown whether these abnormalities present in FH children and contribute to their vascular dysfunction. METHODS AND RESULTS: We studied 38 children with FH (19 males, 19 females aged 14.8+/-0.9 years mean+/-S.E.) and 41 healthy children (con...

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Journal:
Atherosclerosis
Volume:
204
Issue:
2
Pages:
532-537
Publication date:
2009-06-01
DOI:
EISSN:
1879-1484
ISSN:
0021-9150
Source identifiers:
223270

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