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Journal article

CD8 helps TCR catch slippery self pMHC

Abstract:
A new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41590-018-0261-5

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-5847-5226
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
Role:
Author
Publisher:
Springer Nature Publisher's website
Journal:
Nature Immunology Journal website
Volume:
19
Issue:
12
Pages:
1280–1281
Publication date:
2018-11-12
Acceptance date:
2018-10-04
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pubs id:
pubs:929149
URN:
uri:2340d7ce-167b-437a-9415-ab6ddb3c423b
UUID:
uuid:2340d7ce-167b-437a-9415-ab6ddb3c423b
Local pid:
pubs:929149

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