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Baculovirus as delivery system for gene transfer during hypothermic organ preservation

Abstract:

Concerns over the safety of conventional viral vectors have limited the translation of gene transfer from an exciting experimental procedure to a successful clinical therapy in transplantation. Baculoviruses are insect viruses, but have the ability to enter mammalian cells and deliver potential therapeutic molecules with no evidence of viral replication. This study provides evidence of the ability of recombinant baculovirus to enter mammalian kidneys and livers during cold preservation. Six k...

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Journal:
Transplant International
Volume:
24
Issue:
8
Pages:
820-828
Publication date:
2011-08-01
DOI:
EISSN:
1432-2277
ISSN:
0934-0874
Source identifiers:
167795
Language:
English
Keywords:
Pubs id:
pubs:167795
UUID:
uuid:2340abab-0799-42a0-8944-c73e8c345140
Local pid:
pubs:167795
Deposit date:
2013-02-20

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