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Journal article

Axonal and oligodendrocyte-localized IgM and IgG deposits in MS lesions.

Abstract:

BACKGROUND: Recent findings support the important role of antibodies in multiple sclerosis (MS) physiopathology. Thus, local IgG synthesis is a hallmark of the disease, and intrathecal IgM synthesis associates with a poor disease outcome. METHODOLOGY: The aim of this study was to investigate the presence of IgM and IgG in demyelinating lesions using high sensitivity immunohistochemistry techniques in necropsies from fourteen MS patients, four controls without neurological disease and four cas...

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Publication status:
Published

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Journal:
Journal of neuroimmunology More from this journal
Volume:
247
Issue:
1-2
Pages:
86-94
Publication date:
2012-06-01
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
Language:
English
Keywords:
Pubs id:
pubs:325558
UUID:
uuid:233d9725-7cd3-4aeb-a553-637347314676
Local pid:
pubs:325558
Source identifiers:
325558
Deposit date:
2012-12-19

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