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Journal article

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

Abstract:

DNA methylation is a dynamic epigenetic mark that undergoes extensive changes during differentiation of self-renewing stem cells. However, whether these changes are the cause or consequence of stem cell fate remains unknown. Here, we show that alternative functional programs of hematopoietic stem cells (HSCs) are governed by gradual differences in methylation levels. Constitutive methylation is essential for HSC self-renewal but dispensable for homing, cell cycle control and suppression of ap...

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Publication status:
Published

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Publisher copy:
10.1038/ng.463

Authors


Bröske, AM More by this author
Vockentanz, L More by this author
Kharazi, S More by this author
Mancini, E More by this author
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Journal:
Nature genetics
Volume:
41
Issue:
11
Pages:
1207-1215
Publication date:
2009-11-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:233b1822-df92-450c-a108-e1b2f23b644c
Source identifiers:
28189
Local pid:
pubs:28189

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