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Journal article

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

Abstract:

DNA methylation is a dynamic epigenetic mark that undergoes extensive changes during differentiation of self-renewing stem cells. However, whether these changes are the cause or consequence of stem cell fate remains unknown. Here, we show that alternative functional programs of hematopoietic stem cells (HSCs) are governed by gradual differences in methylation levels. Constitutive methylation is essential for HSC self-renewal but dispensable for homing, cell cycle control and suppression of ap...

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Publication status:
Published

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Publisher copy:
10.1038/ng.463

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Journal:
Nature genetics
Volume:
41
Issue:
11
Pages:
1207-1215
Publication date:
2009-11-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
28189

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