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Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.

Abstract:

BACKGROUND AND PURPOSE: Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases. METHODS: Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genome-wide Replication and Meta-analysis (CARDIoGRAM), and Coronary Artery Disease (C4D) Genetics consortia. We first analyzed common varian...

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Publication status:
Published

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Journal:
Stroke; a journal of cerebral circulation
Volume:
45
Issue:
1
Pages:
24-36
Publication date:
2014-01-05
DOI:
EISSN:
1524-4628
ISSN:
0039-2499
URN:
uuid:2338b096-e57b-4619-b120-4563f0d0c71a
Source identifiers:
440285
Local pid:
pubs:440285

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