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Journal article

Tridimensional visualization and analysis of early human development

Abstract:

Generating a precise cellular and molecular cartography of the human embryo is essential to our understanding of the mechanisms of organogenesis in normal and pathological conditions. Here, we have combined whole-mount immunostaining, 3DISCO clearing, and light-sheet imaging to start building a 3D cellular map of the human development during the first trimester of gestation. We provide high-resolution 3D images of the developing peripheral nervous, muscular, vascular, cardiopulmonary, and uro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2017.03.008

Authors


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Role:
Author
ORCID:
0000-0003-4706-2711
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0002-6824-6854
Publisher:
Elsevier
Journal:
Cell More from this journal
Volume:
169
Issue:
1
Pages:
161-173.e12
Publication date:
2017-03-23
Acceptance date:
2017-03-03
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pmid:
28340341

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