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A high-throughput ratiometric method for imaging hypertrophic growth in cultured primary cardiac myocytes

Abstract:

Maladaptive hypertrophy of cardiac myocytes increases the risk of heart failure. The underlying signaling can be triggered and interrogated in cultured neonatal ventricular myocytes (NRVMs) using sophisticated pharmacological and genetic techniques. However, the methods for quantifying cell growth are, by comparison, inadequate. The lack of quantitative, calibratable and computationally-inexpensive high-throughput technology has limited the scope for using cultured myocytes in large-scale ana...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Elsevier
Journal:
Journal of Molecular and Cellular Cardiology More from this journal
Volume:
130
Pages:
184-196
Publication date:
2019-04-13
Acceptance date:
2019-04-04
DOI:
ISSN:
0022-2828
Language:
English
Keywords:
Pubs id:
pubs:989379
UUID:
uuid:2333de80-d7bd-411a-ae37-c378002df7b7
Local pid:
pubs:989379
Source identifiers:
989379
Deposit date:
2019-04-15

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