Journal article
The gating mechanism in cyclic nucleotide-gated ion channels
- Abstract:
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Cyclic nucleotide-gated (CNG) channels mediate transduction in several sensory neurons. These channels use the free energy of CNs’ binding to open the pore, a process referred to as gating. CNG channels belong to the superfamily of voltage-gated channels, where the motion of the α-helix S6 controls gating in most of its members. To date, only the open, cGMP-bound, structure of a CNG channel has been determined at atomic resolution, which is inadequate to determine the molecular events underly...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
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- Files:
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(pdf, 5.0MB)
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- Publisher copy:
- 10.1038/s41598-017-18499-0
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Research Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 8
- Pages:
- Article: 45
- Publication date:
- 2018-01-08
- Acceptance date:
- 2017-12-04
- DOI:
- EISSN:
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2045-2322
- Pubs id:
-
pubs:820203
- URN:
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uri:232bc648-defc-4433-a446-3357cc41a805
- UUID:
-
uuid:232bc648-defc-4433-a446-3357cc41a805
- Local pid:
- pubs:820203
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- Mazzolini et al.
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- License:
- CC BY
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