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The gating mechanism in cyclic nucleotide-gated ion channels

Abstract:

Cyclic nucleotide-gated (CNG) channels mediate transduction in several sensory neurons. These channels use the free energy of CNs’ binding to open the pore, a process referred to as gating. CNG channels belong to the superfamily of voltage-gated channels, where the motion of the α-helix S6 controls gating in most of its members. To date, only the open, cGMP-bound, structure of a CNG channel has been determined at atomic resolution, which is inadequate to determine the molecular events underly...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41598-017-18499-0

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics
Subgroup:
Condensed Matter Physics
Role:
Author
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Role:
Author
ORCID:
0000-0002-8219-1642
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Role:
Author
ORCID:
0000-0001-9214-7269
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Grant:
Project no. 604263
Publisher:
Nature Research Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
Article: 45
Publication date:
2018-01-08
Acceptance date:
2017-12-04
DOI:
EISSN:
2045-2322
Pubs id:
pubs:820203
URN:
uri:232bc648-defc-4433-a446-3357cc41a805
UUID:
uuid:232bc648-defc-4433-a446-3357cc41a805
Local pid:
pubs:820203
Language:
English
Keywords:

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