Journal article icon

Journal article

Assessment of the Plasmodium falciparum pre-erythrocytic antigen UIS3 as a potential candidate for a malaria vaccine

Abstract:

Efforts are currently underway to improve the efficacy of sub-unit malaria vaccines through assessment of new adjuvants, vaccination platforms and antigens. In this study, we further assess the antigen P. falciparum (Pf) upregulated in infective sporozoites 3 (PfUIS3) as a vaccine candidate. PfUIS3 was expressed in the viral vectors chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) and used to immunize mice in a prime-boost regimen. We previously demonstrated that thi...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1128/IAI.00641-16

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Hill, A
Grant:
095540/Z/11/Z
095540/Z/11/Z
More from this funder
Name:
European Research Council
Funding agency for:
Halbroth, B
Grant:
FP7/2012-2016-ERC316655
Publisher:
American Society for Microbiology
Journal:
Infection and Immunity More from this journal
Volume:
85
Issue:
3
Pages:
e00641-16
Publication date:
2016-12-28
Acceptance date:
2016-12-20
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
Language:
English
Pubs id:
pubs:667769
UUID:
uuid:23288ee8-9b62-453c-bc7f-6152a96a9912
Local pid:
pubs:667769
Deposit date:
2017-01-05

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP