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Osteonecrosis of the jaw and the role of macrophages.

Abstract:

Nitrogen-containing bisphosphonates have been associated with the development of osteonecrosis of the jaws (ONJ), but the lack of reliable epidemiological data and appropriate animal models has restricted our understanding of ONJ pathophysiology and limited its management. The best available information is from histopathologic findings, which implicate bone necrosis and infection, although it is not clear which is primary. However, there are data suggesting that macrophages could well be the ...

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Publication status:
Published

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Publisher copy:
10.1093/jnci/djq516

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Journal of the National Cancer Institute
Volume:
103
Issue:
3
Pages:
232-240
Publication date:
2011-02-05
DOI:
EISSN:
1460-2105
ISSN:
0027-8874
URN:
uuid:23282bf9-cc21-4974-a310-d3212e8ffa96
Source identifiers:
269054
Local pid:
pubs:269054

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