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Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients.

Abstract:

Here we report a unique situation in which an early and synchronized Epstein-Barr virus (EBV) reactivation was induced by a 6-day course of treatment with a humanized CD3-specific monoclonal antibody in patients with recent onset of type 1 diabetes. The virologic and immunologic analysis demonstrated that this reactivation was transient, self-limited, and isolated, associated with the rapid advent of an EBV-specific T-cell response. The anti-CD3 antibody administration induced short-lasting i...

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Publication status:
Published

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Journal:
Blood
Volume:
115
Issue:
6
Pages:
1145-1155
Publication date:
2010-02-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
49020

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