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Characterization of meningococcal serogroup B outer membrane vesicle vaccines from strain 44/76 after growth in different media.

Abstract:

In this study, we evaluated the effect of the growth medium on the composition and immunogenicity of meningococcal outer membrane vesicle (OMV) vaccines after cultivation of the Norwegian serogroup B 44/76 vaccine strain in either Frantz' or modified Catlin-6 media (MC.6M). Differential proteomic analysis revealed that 97% of the OMV proteins maintained the same levels in the two preparations. However, a number of differentially expressed proteins, including TdfH, OpcA, OMP NMB0088, hypotheti...

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Journal:
Vaccine
Volume:
28
Issue:
18
Pages:
3211-3218
Publication date:
2010-04-01
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Source identifiers:
249472
Language:
English
Keywords:
Pubs id:
pubs:249472
UUID:
uuid:2322ad5c-d80e-4a4d-bb90-cdec91d0786b
Local pid:
pubs:249472
Deposit date:
2012-12-19

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