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Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

Abstract:

Genome-wide association studies have revealed that common noncoding variants in MTNR1B (encoding melatonin receptor 1B, also known as MT 2) increase type 2 diabetes (T2D) risk. Although the strongest association signal was highly significant (P < 1 - 10 g 20), its contribution to T2D risk was modest (odds ratio (OR) of g1/41.10g1.15). We performed large-scale exon resequencing in 7,632 Europeans, including 2,186 individuals with T2D, and identified 40 nonsynonymous variants, including 36 v...

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Publisher copy:
10.1038/ng.1053

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Journal:
Nature Genetics
Volume:
44
Issue:
3
Pages:
297-301
Publication date:
2012-03-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
320778
Language:
English
Pubs id:
pubs:320778
UUID:
uuid:23207884-f30c-4c0a-9b99-973773db4314
Local pid:
pubs:320778
Deposit date:
2012-12-19

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