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The two-year progression of structural and functional cerebral MRI in amyotrophic lateral sclerosis

Abstract:

MRI has emerged as one of several urgently needed candidate disease progression biomarkers for the neurodegenerative disorder amyotrophic lateral sclerosis (ALS), not least due to its unique ability to non-invasively assess structural and functional cerebral pathology. We sought to identify the extent of detectable change in cerebral MRI metrics over a more prolonged period. Analysis of multi-modal MRI data was performed in a cohort of sixteen patients (13 ALS and 3 with primary lateral scler...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.nicl.2017.12.025

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
ORCID:
0000-0003-0267-3180
Publisher:
Elsevier Publisher's website
Journal:
NeuroImage: Clinical Journal website
Volume:
17
Pages:
953-961
Publication date:
2017-12-18
Acceptance date:
2017-12-07
DOI:
ISSN:
2213-1582
Pubs id:
pubs:810360
URN:
uri:231ce1b6-6dce-4ac8-a0bc-1a4061a42dfc
UUID:
uuid:231ce1b6-6dce-4ac8-a0bc-1a4061a42dfc
Local pid:
pubs:810360

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