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Tyrosine depletion attenuates the behavioural stimulant effects of amphetamine and cocaine in rats.

Abstract:

Neurochemical studies show that a tyrosine-free amino acid mixture depletes brain tyrosine and decreases dopamine synthesis and release. Here, we tested whether such a mixture would reduce the behavioural effects of amphetamine and other psychostimulants. A tyrosine-free amino acid mixture decreased the behavioural activation induced by both D-amphetamine (2 mg/kg s.c.) and cocaine (2 mg/kg s.c.). In contrast, the activation induced by the dopamine agonist, apomorphine (0.75 and 5 mg/kg s.c.)...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
European journal of pharmacology More from this journal
Volume:
424
Issue:
2
Pages:
115-119
Publication date:
2001-07-01
DOI:
EISSN:
1879-0712
ISSN:
0014-2999
Language:
English
Keywords:
Pubs id:
pubs:139876
UUID:
uuid:23177238-476b-4ab8-8a96-91f63b8b5994
Local pid:
pubs:139876
Source identifiers:
139876
Deposit date:
2012-12-19

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