Journal article
The drebrin/EB3 pathway drives invasive activity in prostate cancer
- Abstract:
-
Prostate cancer is the most common cancer in men and the metastatic form of the disease is incurable. We show here that the drebrin/EB3 pathway, which co-ordinates dynamic microtubule/actin filament interactions underlying cell shape changes in response to guidance cues, plays a role in prostate cancer cell invasion. Drebrin expression is restricted to basal epithelial cells in benign human prostate but is upregulated in luminal epithelial cells in foci of prostatic malignancy. Drebrin is als...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Medical Research Council
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King’s Health Partners’ Research and Development Challenge Fund
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Oncogene Journal website
- Volume:
- 36
- Issue:
- 29
- Pages:
- 4111-4123
- Publication date:
- 2017-03-20
- Acceptance date:
- 2017-02-02
- DOI:
- EISSN:
-
1476-5594
- ISSN:
-
0950-9232
- Pmid:
-
28319065
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:686855
- UUID:
-
uuid:2313f444-5252-4448-8922-fadcb9426641
- Local pid:
- pubs:686855
- Source identifiers:
-
686855
- Deposit date:
- 2018-02-01
Terms of use
- Copyright holder:
- Dart et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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