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A preliminary neuropathological study of Japanese encephalitis in humans and a mouse model.

Abstract:

Japanese encephalitis virus is a mosquito-borne flavivirus that causes approximately 10000 deaths annually in Asia. After a brief viraemia, the virus enters the central nervous system, but the means of crossing the blood-brain barrier is uncertain. We used routine histological staining, immunohistology and electron microscopy to examine brain material from four fatal human cases, and made comparisons with material from a mouse model. In human material there was oedema, perivascular inflammati...

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Publication status:
Published

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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene More from this journal
Volume:
100
Issue:
12
Pages:
1135-1145
Publication date:
2006-12-01
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
Language:
English
Keywords:
Pubs id:
pubs:40112
UUID:
uuid:23114c78-97f0-4a5e-8a55-a3116f2b2ec2
Local pid:
pubs:40112
Source identifiers:
40112
Deposit date:
2012-12-19

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