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An open-trial evaluation of mitoxantrone in the treatment of progressive MS.

Abstract:

We treated 13 patients with progressive MS with mitoxantrone. All patients received a standard IV dose of mitoxantrone (8 mg/m2) every 3 weeks for a total of seven infusions, with dosage adjustments depending on the hematologic profile at the nadir. The treatment was well tolerated, with the most common side effect being mild nausea. Four of seven women developed transient secondary amenorrhea. The postenrollment clinical behavior of these patients was generally more favorable than during the...

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Publication status:
Published

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Publisher copy:
10.1212/wnl.43.7.1401

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Journal:
Neurology More from this journal
Volume:
43
Issue:
7
Pages:
1401-1406
Publication date:
1993-07-01
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
Language:
English
Keywords:
Pubs id:
pubs:44187
UUID:
uuid:23112c42-585d-48ea-a575-4471ce0064f1
Local pid:
pubs:44187
Source identifiers:
44187
Deposit date:
2012-12-19

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