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Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13. Age-related differences in effect.

Abstract:

Previous studies have suggested the presence of quantitative trait loci (QTLs) influencing blood pressure on rat chromosomes 2 and 13. In this study, we mapped the QTLs in F2 rats derived from a cross of the spontaneously hypertensive rat and the Wistar-Kyoto rat and analyzed the effect of the QTLs on blood pressures measured longitudinally between 12 and 25 weeks of age. We analyzed 16 polymorphic markers spanning 147.3 cM on chromosome 2 and 13 markers spanning 91.6 cM on chromosome 13. Bot...

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Publication status:
Published

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Publisher copy:
10.1161/01.hyp.28.6.1118

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Journal:
Hypertension
Volume:
28
Issue:
6
Pages:
1118-1122
Publication date:
1996-12-01
Event title:
Genetics 96 - Satellite Symposium of the International-Society-of-Hypertension
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Source identifiers:
17767
Keywords:
Pubs id:
pubs:17767
UUID:
uuid:2311156a-83b2-4aee-bf41-fc2ab7d7bd28
Local pid:
pubs:17767
Deposit date:
2012-12-19

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