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Th17: contributors to allograft rejection and a barrier to the induction of transplantation tolerance?

Abstract:

T helper (Th) type 17 cells are a recently described CD4 T-cell subset that may contribute to allograft rejection and act as a barrier to the induction of transplant tolerance. This review examines the involvement of Th17 cells in transplant rejection, how immunosuppressive medication may affect their induction and maintenance and the potential plasticity of developing Th17 cells. It also addresses the complex interplay between the Th17 and regulatory T-cell developmental pathways and the sus...

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Publication status:
Published

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Publisher copy:
10.1097/TP.0b013e3182126eeb

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Transplantation
Volume:
91
Issue:
9
Pages:
939-945
Publication date:
2011-05-01
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
Source identifiers:
136048
Language:
English
Keywords:
Pubs id:
pubs:136048
UUID:
uuid:23103a45-759f-4a25-8fe6-ca4361c641c0
Local pid:
pubs:136048
Deposit date:
2012-12-19

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