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Th17: contributors to allograft rejection and a barrier to the induction of transplantation tolerance?

Abstract:

T helper (Th) type 17 cells are a recently described CD4 T-cell subset that may contribute to allograft rejection and act as a barrier to the induction of transplant tolerance. This review examines the involvement of Th17 cells in transplant rejection, how immunosuppressive medication may affect their induction and maintenance and the potential plasticity of developing Th17 cells. It also addresses the complex interplay between the Th17 and regulatory T-cell developmental pathways and the sus...

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Publication status:
Published

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Publisher copy:
10.1097/TP.0b013e3182126eeb

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Journal:
Transplantation
Volume:
91
Issue:
9
Pages:
939-945
Publication date:
2011-05-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:23103a45-759f-4a25-8fe6-ca4361c641c0
Source identifiers:
136048
Local pid:
pubs:136048

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