Journal article
A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression.
- Abstract:
-
Tumor necrosis factor-stimulated gene-6 (TSG-6) encodes a 35-kDa protein, which is comprised of contiguous Link and CUB modules. TSG-6 protein has been detected in the articular joints of osteoarthritis (OA) patients, with little or no constitutive expression in normal adult tissues. It interacts with components of cartilage matrix (e.g. hyaluronan and aggrecan) and thus may be involved in extracellular remodeling during joint disease. In addition, TSG-6 has been found to have anti-inflammato...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m110765200
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Authors
Bibliographic Details
- Journal:
- The Journal of biological chemistry
- Volume:
- 277
- Issue:
- 18
- Pages:
- 15354-15362
- Publication date:
- 2002-05-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:230fe7b6-31b6-479f-9bd9-b5f6062df8e8
- Source identifiers:
-
54000
- Local pid:
- pubs:54000
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2002
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