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Journal article

A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression.

Abstract:

Tumor necrosis factor-stimulated gene-6 (TSG-6) encodes a 35-kDa protein, which is comprised of contiguous Link and CUB modules. TSG-6 protein has been detected in the articular joints of osteoarthritis (OA) patients, with little or no constitutive expression in normal adult tissues. It interacts with components of cartilage matrix (e.g. hyaluronan and aggrecan) and thus may be involved in extracellular remodeling during joint disease. In addition, TSG-6 has been found to have anti-inflammato...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110765200

Authors


Nentwich, HA More by this author
Mustafa, Z More by this author
Marsden, BD More by this author
Cordell, MR More by this author
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Journal:
The Journal of biological chemistry
Volume:
277
Issue:
18
Pages:
15354-15362
Publication date:
2002-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:230fe7b6-31b6-479f-9bd9-b5f6062df8e8
Source identifiers:
54000
Local pid:
pubs:54000

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