Journal article
Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death
- Abstract:
-
Expression of the transcription factor brachyury (TBXT) is normally restricted to the embryo and its silencing is epigenetically regulated. TBXT promotes mesenchymal transition in a subset of common carcinomas, and in chordoma, a rare cancer showing notochordal differentiation, TBXT acts as a putative oncogene. We hypothesized that TBXT expression is controlled through epigenetic inhibition to promote chordoma cell death. Screening of five human chordoma cell lines revealed that pharmacologic...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Sarcoma UK
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Fondation Leducq
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Bibliographic Details
- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Cancer Research Journal website
- Volume:
- 80
- Issue:
- 20
- Pages:
- 4540-4551
- Publication date:
- 2020-08-27
- Acceptance date:
- 2020-08-19
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1129443
- Local pid:
- pubs:1129443
- Deposit date:
- 2020-09-01
Terms of use
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2020
- Rights statement:
- Copyright ©2020, American Association for Cancer Research.
- Notes:
-
This is the accepted manuscript version of the article. The final version is available from American Association for Cancer Research at https://doi.org/10.1158/0008-5472.CAN-20-1387
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