MRI measurement of oxygen extraction fraction, mean vessel size and cerebral blood volume using serial hyperoxia and hypercapnia.

Journal article

Functional magnetic resonance imaging measures signal increases arising from a variety of interrelated effects and physiological sources. Recently there has been some success in disentangling this signal in order to quantify baseline physiological parameters, including the resting oxygen extraction fraction (OEF), cerebral blood volume (CBV) and mean vessel size. However, due to the complicated nature of the signal, each of these methods relies on certain physiological assumptions to derive a...

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Authors: Germuska, M; Bulte, D

• Publisher: Academic Press Inc.
• Journal: NeuroImage
• Volume: 92
• Pages: 132-142
• Publication date: 2014-05-01
• DOI: 10.1016/j.neuroimage.2014.02.002
• EISSN: 1095-9572
• ISSN: 1053-8119
• Language: English
• Keywords: Oximetry; Humans; Blood Volume; Blood Flow Velocity; Hypercapnia; Adult; Organ Size; Magnetic Resonance Imaging; Male; Reproducibility of Results; Hyperoxia; Oxygen; Imaging, Three-Dimensional; Cerebral Arteries; Female; Sensitivity and Specificity; Cerebrovascular Circulation; Blood Volume Determination