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High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle.

Abstract:

Evidence suggests the transcription factor GATA-2 is a critical regulator of murine hematopoietic stem cells. Here, we explore the relation between GATA-2 and cell proliferation and show that inducing GATA-2 increases quiescence (G(0) residency) of murine and human hematopoietic cells. In human cord blood, quiescent fractions (CD34(+)CD38(-)Hoechst(lo)Pyronin Y(lo)) express more GATA-2 than cycling counterparts. Enforcing GATA-2 expression increased quiescence of cord blood cells, reducing pr...

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Publication status:
Published

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Journal:
Blood More from this journal
Volume:
113
Issue:
12
Pages:
2661-2672
Publication date:
2009-03-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971

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