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Activity of defined mushroom body output neurons underlies learned olfactory behavior in Drosophila

Abstract:

During olfactory learning in fruit flies, dopaminergic neurons assign value to odor representations in the mushroom body Kenyon cells. Here we identify a class of downstream glutamatergic mushroom body output neurons (MBONs) called M4/6, or MBON-β2β'2a, MBON-β'2mp, and MBON-γ5β'2a, whose dendritic fields overlap with dopaminergic neuron projections in the tips of the β, β', and γ lobes. This anatomy and their odor tuning suggests that M4/6 neurons pool odor-driven Kenyon cell synaptic output...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
Cell Press
Journal:
Neuron More from this journal
Volume:
86
Issue:
2
Pages:
417-427
Publication date:
2015-04-09
Acceptance date:
2015-02-20
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Language:
English
Keywords:
Pubs id:
pubs:517695
UUID:
uuid:230535e1-6c8a-4aff-ad31-de389e006335
Local pid:
pubs:517695
Source identifiers:
517695
Deposit date:
2016-07-13

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